Faculty of Computer Science and Engineering# Shahid Beheshti University# Tehran# Iran
Abstract
Hepatitis C is a serious disease that cannot easily be diagnosed at the early stages of this illness. Recently, microRNA are introduced as an efficient biomarker for detecting it. Real-time PCR (The Polymerase Chain Reaction) is the most popular method to profile the microRNA expression. However, it is costly, time-consuming and its accuracy is not sufficient for the very few levels of these biomarkers. Recently, DNA logic gates are used to detect the microRNA expression volume. We presented a DNA-based logic system to detect the pattern of hepatitis C viral infection. The higher number of microRNAs that are detected means the diagnosis is more reliable, and the possibility of a false positive is less. The proposed system has no limits on the number of inputs. We tested it with 20 microRNAs of hepatitis-C viral infection. The results show that this gate can detect complicated patterns with higher fan-in, lower complexity/cost, better response time, and higher accuracy rather than real-time PCR.
Sadat Masoud,M. , Sanjabi,M. and Jahanian,A. (2021). Multi-input DNA-based Logic Gates for Profiling the MicroRNA Biomarkers of Hepatitis-C Viral Infection. The CSI Journal on Computer Science and Engineering, 18(2), 16-23.
MLA
Sadat Masoud,M. , , Sanjabi,M. , and Jahanian,A. . "Multi-input DNA-based Logic Gates for Profiling the MicroRNA Biomarkers of Hepatitis-C Viral Infection", The CSI Journal on Computer Science and Engineering, 18, 2, 2021, 16-23.
HARVARD
Sadat Masoud M., Sanjabi M., Jahanian A. (2021). 'Multi-input DNA-based Logic Gates for Profiling the MicroRNA Biomarkers of Hepatitis-C Viral Infection', The CSI Journal on Computer Science and Engineering, 18(2), pp. 16-23.
CHICAGO
M. Sadat Masoud, M. Sanjabi and A. Jahanian, "Multi-input DNA-based Logic Gates for Profiling the MicroRNA Biomarkers of Hepatitis-C Viral Infection," The CSI Journal on Computer Science and Engineering, 18 2 (2021): 16-23,
VANCOUVER
Sadat Masoud M., Sanjabi M., Jahanian A. Multi-input DNA-based Logic Gates for Profiling the MicroRNA Biomarkers of Hepatitis-C Viral Infection. CSIonJCSE, 2021; 18(2): 16-23.
The CSI Journal on Computer Science and Engineering